Shanghai EGT Synbio Group Participates in Nutra Healthspan Summit 2025

From November 12 to 13, 2025, the Nutra Healthspan Summit 2025 was held in London, bringing together scientists, ingredient innovators, nutrition brands, and industry stakeholders to discuss the future of healthy aging.

Organized by the NutraIngredients team, the summit focused on translating aging science into practical nutrition and dietary supplement solutions. Topics included cellular health, NAD+ metabolism, mitochondrial function, antioxidant protection, and the development of evidence-based healthy aging products.

As a company specializing in synthetic biology and functional ingredients, Shanghai EGT Synbio Group Co., Ltd. participated in the summit as an industry partner, joining global discussions on how nutrition science can support longer healthspan through more targeted, science-backed ingredient strategies.

During the summit, the panel discussion “Unlocking the Power of NAD+ Precursors" became one of the key sessions. The discussion was moderated by Professor Andrea B. Maier, Co-Director of the Centre for Healthy Longevity at the National University of Singapore and a leading researcher in aging science.

The panel brought together representatives from academia and industry, including Mr. Zhang Wei, General Manager of Shanghai EGT Synbio Group Co., Ltd., to discuss the current development path of NAD+ support ingredients.

NAD+ has attracted broad scientific and commercial interest due to its role in energy metabolism, cellular repair, and healthy aging. However, the market also faces several challenges, including product homogenization, unclear differentiation, and the need for stronger evidence-based formulation strategies.

During the discussion, Mr. Zhang Wei emphasized that the future of NAD+ support should move beyond single-ingredient competition. Instead, the industry may benefit from a more systematic approach that considers both NAD+ replenishment and cellular protection.

In this framework, NAD+ precursors such as NMN may help support NAD+ biosynthesis, while antioxidant ingredients such as L-ergothioneine may help reduce oxidative stress-related burden in cells. Together, this approach provides a broader formulation concept for brands developing healthy aging products.

NAD+, or nicotinamide adenine dinucleotide, is a coenzyme that plays an essential role in cellular energy metabolism. It is involved in redox reactions, mitochondrial function, DNA repair, and other biological processes related to cellular homeostasis.

Recent aging research has also explored the relationship between NAD+ metabolism and long-lived populations. According to the original company draft, a recent preprint study from Boston University used metabolomics analysis to investigate metabolic characteristics among 213 participants, including centenarians.

The study discussed metabolic features related to tryptophan, kynurenine, quinolinic acid, and NAD+ pathways. These findings suggest that NAD+ metabolism may be an important part of the broader biological network associated with healthy aging.

It is important to note that preprint studies should be interpreted cautiously until peer review is completed. For industry communication, such findings are best positioned as emerging scientific observations, rather than final clinical conclusions.

As healthy aging consumers become more science-aware, formulation strategies are also changing. Instead of relying on one ingredient or one pathway, brands are increasingly exploring multi-ingredient systems that address cellular energy, oxidative stress, inflammation, mitochondrial function, and metabolic balance together.

Within this trend, the combination of NAD+ support ingredients and L-ergothioneine provides an interesting formulation direction.

NAD+ precursors such as NMN are designed to support NAD+ biosynthesis. Some human studies have investigated the effects of NMN supplementation on NAD+ levels, physical function, and biological aging-related markers.

The original company draft refers to a 2021 study that associated NMN supplementation with changes in telomere length in healthy middle-aged men. However, telomere biology is complex, and more research is needed before making strong conclusions about long-term aging outcomes.

For compliant product communication, NMN should be positioned around NAD+ support, cellular energy metabolism, and healthy aging research, rather than as a direct anti-aging treatment.

L-ergothioneine is a naturally occurring sulfur-containing amino acid derivative found in foods such as mushrooms. It has attracted attention due to its antioxidant properties and its association with the specific human transporter OCTN-1.

In healthy aging formulations, L-ergothioneine may help support antioxidant defense and cellular protection. This makes it a relevant complementary ingredient for brands developing NAD+ support products, especially when the product concept aims to address both energy metabolism and oxidative stress.

Together, NAD+ precursors and L-ergothioneine can form a more complete healthy aging formulation narrative: supporting cellular energy on one side and antioxidant defense on the other.

Shanghai EGT Synbio Group Co., Ltd. is a high-tech enterprise specializing in synthetic biology and biotransformation technologies. The company focuses on the research, development, manufacturing, and application of natural active ingredients for healthy aging, oral beauty, functional nutrition, and personal care.

Its flagship ingredient Dr.Ergo® L-Ergothioneine is positioned as a high-purity, fermentation-derived antioxidant ingredient for premium nutrition and beauty-from-within applications. According to company product information, Dr.Ergo® L-Ergothioneine is suitable for multiple dosage forms, including capsules, tablets, powders, beauty drinks, gummies, jellies, and other functional nutrition products.

Driven by scientific research, quality manufacturing, and global regulatory support, Shanghai EGT Synbio Group Co., Ltd. continues to provide science-backed ingredient solutions for global brands in dietary supplements, functional foods, oral beauty, and healthy aging.

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