Protective Effect of Ergothioneine against Oxidative Stress-Induced Chondrocyte Death

Title: Protective Effect of Ergothioneine against Oxidative Stress-Induced Chondrocyte Death

Conclusion: In this in vitro study, the database relates the work to antioxidant / cellular protection; inflammation-related research; healthy aging. EGT improved cell viability, reduced LDH release, dead-cell proportion, and ROS, and helped preserve mitochondrial morphology in an oxidative-stress chondrocyte model. The current database classifies the evidence level as limited. The conclusion should remain tied to the study model and endpoint described in the database, and should not be generalized beyond the source type or used as a disease-treatment claim. Additional interpretation should remain conservative and should distinguish cellular, animal, observational, review, and human intervention evidence.