Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF-kB axis both in vitro and in vivo

Title: Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF-kB axis both in vitro and in vivo

Conclusion: In this animal study, the database relates the work to inflammation-related research; antioxidant / cellular protection; healthy aging. EGT reduced inflammatory mediators and extracellular-matrix degradation markers in cell and mouse osteoarthritis models through a Sirt6/NF-kB-related pathway. The current database classifies the evidence level as limited. The conclusion should remain tied to the study model and endpoint described in the database, and should not be generalized beyond the source type or used as a disease-treatment claim. Additional interpretation should remain conservative and should distinguish cellular, animal, observational, review, and human intervention evidence.