Mushrooms L-Ergothioneine Antioxidant Powder 99.9% Sleep Brain & Longevity Antioxidant

DR.ERGO® is a next-generation antioxidant ingredient — a naturally occurring sulfur-containing amino acid (L-Ergothioneine, or EGT) that science has increasingly recognized as a potential "longevity vitamin." Unlike typical dietary compounds, ergothioneine behaves much like a vitamin in humans: the body cannot synthesize it on its own, yet it possesses a dedicated cell membrane transporter protein — OCTN-1 — specifically built to absorb and retain it, underscoring its fundamental importance to cellular function.

DR.ERGO® is produced using a proprietary green biofermentation technology, achieving a purity of ≥99.9% in an ultra-stable crystalline form — free from allergens, and patented by the Chinese Academy of Sciences.

There is mounting evidence for the potential of L-ergothioneine, a natural dietary antioxidant and anti-inflammatory amino acid, to prevent or mitigate chronic diseases of aging — leading researchers to propose it as a candidate "longevity vitamin."

Some leading scientists now describe ergothioneine as a potential longevity nutrient due to how specifically the body absorbs and distributes it, with recent research linking it to NAD+ boosting, cognitive protection, and anti-aging mechanisms.

What makes EGT unique is its exclusive cellular transporter. In mammals, ergothioneine is not generated in the body but is acquired from the diet via the carnitine/organic cation transporter OCTN1/SLC22A4, which is widely expressed in various organs and cells and is responsible for EGT's unique tissue distribution — with efficient reabsorption in the kidneys preventing rapid excretion. This means DR.ERGO® doesn't merely circulate — it is actively retained and concentrated where the body needs it most.

One of the most compelling and novel applications of ergothioneine is its effect on sleep — a benefit now supported by multiple independent clinical trials.

In a 16-week randomized, double-blind, placebo-controlled trial involving 147 adults aged 55–79 with subjective memory complaints, participants received ergothioneine (10 mg or 25 mg/day) or placebo. The 25 mg/day group showed a significant, dose-dependent improvement in sleep onset as measured by the Leeds Sleep Evaluation Questionnaire (LSEQ).

In a separate Japanese randomized placebo-controlled study, volunteers with high anxiety and sleep complaints who took ergothioneine daily for 4 weeks showed significant improvements in both subjective sleep difficulty and objective sleep quality as measured by electroencephalography (EEG). Metabolome analysis further revealed that EGT reduces consumption of antioxidant substances while enhancing lipid metabolism.

Research using physiologically based pharmacokinetic (PBPK) modeling confirms that ergothioneine's sleep-supporting effects are dose-dependent, and that sustained daily supplementation is an effective strategy for improving sleep outcomes.

Clinical studies suggest that ergothioneine supports learning performance and reduces neuronal injury biomarkers in older adults with mild cognitive impairment, with sleep quality and cognitive benefits observed at doses ranging from 8 to 20 mg/day.

Ergothioneine supplementation increases anti-inflammatory and antioxidant molecules. Importantly, adequate sleep — which EGT actively supports — is itself associated with a 48% lower risk of all-cause mortality, making ergothioneine's dual role in sleep and antioxidant defense particularly significant for healthy aging.

Ergothioneine shows superior free radical scavenging activity compared to other conventional antioxidants such as glutathione, Trolox (a vitamin E analogue), and uric acid. It is also notably more resistant to auto-oxidation than other thiols like glutathione, owing to its unique thiol-thione tautomeric structure.

DR.ERGO® works through five scientifically documented pathways:

① Modulates Neurotransmitter Balance — Supports the neuroregulatory systems that govern sleep onset, mood, and stress response, helping to ease difficulty falling asleep.

② Reduces Oxidative Stress — As a potent intracellular antioxidant, EGT quenches free radicals within the cytoplasm and mitochondria, protecting neurons, heart cells, and other high-demand tissues from oxidative damage.

③ Stabilizes HPA Axis Activity — By attenuating the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, EGT helps regulate the body's stress-response system, reducing stress-related symptoms that interfere with sleep and cognition.

④ Enhances Brain Energy Metabolism — Recent research found that ergothioneine accumulates in muscle mitochondria and binds to the enzyme 3-mercaptopyruvate sulfurtransferase (MPST), activating hydrogen sulfide production and boosting mitochondrial respiration — a mechanism that also supports brain energy supply and mental clarity.

⑤ Attenuates Neuroinflammation — By reducing inflammatory signaling in neural tissue, EGT supports long-term cognitive resilience and healthy brain aging.

DR.ERGO® holds an industry-leading certification portfolio for global market entry:

FDA GRAS · EU Novel Food · NSF GMP Registered · ISO 22000 · ISO 9001/14001/45001 · HACCP Certified · Halal · Vegan · LBD Vegan Label

Ergothioneine has been established as Generally Recognized as Safe (GRAS) by the U.S. FDA. Even at extremely large doses, no adverse effects were seen in animal studies, and the recommended supplemental dosage level is well below the no observed adverse effect level (NOAEL) established by the European Food Safety Authority (EFSA).

DR.ERGO® is engineered for versatile formulation across solid dosage forms:

• Tablets
• Capsules
• Gels
• Gummies
• Powders
• Jellies

Recommended Use Level: 8–25 mg per daily serving (based on clinical literature)

DR.ERGO® is an ideal B2B ingredient for manufacturers formulating:

• Sleep support supplements targeting adults with sleep onset difficulty or stress-related sleep disruption
• Anti-aging & longevity formulas for health-conscious consumers aged 40+
• Cognitive health products for adults with age-related memory or focus concerns
• Stress & adaptogen blends incorporating neuroregulatory antioxidants
• Functional foods & nutraceuticals requiring high-purity, stable bioactive ingredients

Shanghai EGT Synbio Group Co., Ltd. is a Shanghai-based specialty ingredients company dedicated to the development and supply of science-backed longevity compounds. DR.ERGO® ergothioneine is produced at our certified facility at No.1299 Ziyue Road, Minhang District, Shanghai, China, under ISO 22000, ISO 9001/14001/45001, and HACCP quality management systems.